What's the best website to find the cheapest airfare to Asia from the east coast of the US?

There's not one that's always best. Sometimes an airline has a sale that's cheaper via it's own site, sometimes Expedia or Orbitz turns up a cheaper routing, or sometimes a consolidator might be offering a price that others can't beat--for example. So, you have to shop around. The single best place I've found actually checks hundreds of other places, all in one go so it saves you hours of research time: a href="http://www.bookingbuddy.com" rel="nofollow"http://www.bookingbuddy.com/a -- will check all of the examples I mentioned.